Bayliss, G. J. and Wolf, Hans J.
An Epstein--Barr virus early protein induces cell fusion.
Proceedings of the National Academy of Sciences of the United States of America : PNAS 78 (11), pp. 7162-7165.
Superinfection of Raji cells with Epstein--Barr virus (EBV) leads to syncytium formation. Studies using metabolic inhibitors and amino acid analogues suggest that the fusion-inducing factor belongs to the early group of virus-specified proteins. Induction of early EBV protein synthesis in Raji cells by using various chemicals also leads to syncytium formation, indicating that the fusion process is not caused by a virion membrane protein introduced into the cells upon infection. The relevance of these findings to the association of EBV with carcinoma of the nasopharynx is discussed.
|Institutions:|| Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene|
|Cell Transformation, Viral||MESH|
|Fluorescent Antibody Technique||MESH|
|Herpesvirus 4, Human/immunology||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||03 May 2011 06:22|
|Last Modified:||21 Jul 2011 02:12|