Wu, Meng and Lin, Zhihong and Mirsky, Vladimir and Wolfbeis, Otto S. (2001) Detection of DNA hybridization with surface plasmon resonance biosensor: comparison of immobilization of oligonucleotides by ssDNA and dsDNA. In: Zhou, Yikai, (ed.) Proceedings / International Conference on Sensor Technology (ISTC 2001): 10-12 October 2001, Wuhan, China. Proc. SPIE, 4414. SPIE, the International Society for Optical Engineering, Bellingham, Wash., pp. 23-26. ISBN 0-8194-4119-8.
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In this research, a surface-plasmon resonance biosensor for nucleic acid detection was constructed, optimized and characterized. The kinetic response on hybridization was also studied. The biosensor was use as a platform for the study of the surface coverage control by single-strand or double-strand oligonucleotide immobilization. The dsDNA immobilization and offers a new way to surface coverage control for the nucleic acid biosensor construction.
|Item Type:||Book Section|
|Institutions:||Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Otto S. Wolfbeis)|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||18 Jul 2011 09:41|
|Last Modified:||18 Jul 2011 09:41|