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Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells

Schreck, R. and Meier, B. and Männel, D.N. and Dröge, W. and Baeuerle, P. A. (1992) Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. The Journal of experimental medicine : JEM 175 (5), pp. 1181-1194.

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Abstract

Dithiocarbamates and iron chelators were recently considered for the treatment of AIDS and neurodegenerative diseases. In this study, we show that dithiocarbamates and metal chelators can potently block the activation of nuclear factor kappa B (NF-kappa B), a transcription factor involved in human immunodeficiency virus type 1 (HIV-1) expression, signaling, and immediate early gene activation ...

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Item Type:Article
Date:1992
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
1314883PubMed ID
Classification:
NotationType
Base SequenceMESH
Cell LineMESH
Chelating Agents/pharmacologyMESH
DNAMESH
Dose-Response Relationship, DrugMESH
HumansMESH
Lipopolysaccharides/metabolismMESH
Molecular Sequence DataMESH
NF-kappa B/antagonists & inhibitorsMESH
Pyrrolidines/pharmacologyMESH
Superoxides/metabolismMESH
Thiocarbamates/pharmacologyMESH
Transcriptional Activation/drug effectsMESH
Subjects:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Universitätsbibliothek Regensburg
Deposited On:17 Jun 2011 06:08
Last Modified:13 Mar 2014 17:33
Item ID:21160
Owner Only: item control page

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