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Photosensitization of skin-derived cell lines by Dimegin [2,4-di-(α-methoxyethyl)-deuteroporphyrin IX] in vitro

Fickweiler, S. and Szeimies, R. M. and Abels, C. and Ponomarev, G. V. and Hofstädter, F. and Wolfbeis, Otto S. and Landthaler, M. (1998) Photosensitization of skin-derived cell lines by Dimegin [2,4-di-(α-methoxyethyl)-deuteroporphyrin IX] in vitro. Photodermatology, Photoimmunology & Photomedicine 14 (3-4), pp. 125-131.

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The deuteroporphyrin-IX derivative Dimegin [2,4-di-(α-methoxyethyl)-deuteroporphyrin IX] was investigated with respect to cellular uptake, intracellular localization and cell survival following photodynamic treatment in human cell lines derived from the skin (SCL1 and SCL2, squamous cell carcinoma; HaCaT keratinocytes; N1 fibroblasts). Using flow cytometry, we determined the cellular fluorescence ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Chemo- und Biosensorik (Prof. Antje J. Bäumner, formerly Prof. Wolfbeis)
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Keywords:photodynamic therapy; deuteroporphyrin IX derivative; cell culture study; uptake; localization
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Created at the University of Regensburg:Unknown
Deposited on:18 Jul 2011 10:10
Last modified:13 Mar 2014 17:41
Item ID:21493
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