Doenicke, A. and Lorenz, Wilfried and Beigl, R. and Bezecny, H. and Uhlig, G. and Kalmar, L. and Praetorius, B. and Mann, G.
Histamine release after intravenous application of short-acting hypnotics. A comparison of etomidate, Althesin (CT1341) and propanidid.
British journal of anaesthesia 45 (11), pp. 1097-1104.
The subject of histamine release was investigated in 16 volunteers by means of plasma histamine determination after the administration of etornidate, Althesin, propanidid, and Cremophor EL. Althesin and propanidid caused release of histamine in various degrees of frequency. Blood pressure changes were rather pronounced with both anaesthetic agents; tachycardia reached its maximum in the first and second minute, which seems to be an argument against histamine release as the underlying cause of this reaction. Histamine was, indeed, only released to such an extent (with the exception of one borderline case) that no clinical symptoms other than secretion of gastric juice and erythema were to be expected. After the application of etomidate and Cremophor EL an increase in plasma histamine was not detectable. Changes in the differential blood picture in terms of a decrease in basophils only occurred after Althesin and propanidid; not, however, after etomidate and Cremophor EL. Etomidate is, therefore, the first hypnotic drug for intravenous application which is unlikely to cause chemical histamine release.
|Institutions:|| Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V.|
|Histamine Release/drug effects||MESH|
|Hypnotics and Sedatives/pharmacology||MESH|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Unknown|
|Deposited On:||24 Aug 2011 10:21|
|Last Modified:||24 Aug 2011 10:21|