Drapeau, Jeremy and Verdier, M. and Touraud, Didier and Kröckel, U. and Geier, M. and Rose, A. and Kunz, Werner (2009) Effective insect repellent formulation in both surfactantless and classical microemulsions with a long-lasting protection for human beings. Chemistry & Biodiversity 6 (6), pp. 934-947.
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The aim of this work is to develop a new generation of repellent products with a long-lasting protection based on a natural component, para-menthane-3,8-diol (PMD). The active is first rendered sol. in a surfactantless microemulsion (H2O/iPrOH/PMD) and then in classical microemulsions. The presence of self-assocd. nanostructures is detected by dynamic light scattering (DLS). A synergetic system of surfactants (Cremophor RH40 and Texapon N70) is used. Addnl., 2-ethylhexane-1,3-diol and Et (-)-(S)-lactate are incorporated. The final product contains, as main components, 46% of H2O, 25% of iPrOH, 20% of non-H2O-sol. PMD, and only 4% of surfactants. Investigations of lasting protection on human volunteers are carried out using a cage test bioassay protocol and Aedes aegypti mosquitoes. A complete protection of 315 min is found on the test persons using the surfactantless microemulsion. An extension is obsd. with the final formulation to reach a mean of complete protection of 385 min. This study demonstrates that alternative formulations using a natural active instead of synthetic chems. like N,N-diethyl-m-methylbenzamide (DEET) can be efficient for human protection against mosquitoes.
|Institutions:||Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > Prof. Dr. Werner Kunz|
|Keywords:||Aedes insect repellent formulation menthanediol|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||18 May 2012 07:58|
|Last Modified:||18 May 2012 07:58|