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Modulation and function of microglial phenotypes

URN to cite this document: urn:nbn:de:bvb:355-epub-244776

Karlstetter, Marcus (2012) Modulation and function of microglial phenotypes. PhD, Universität Regensburg

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Abstract (English)

Microglia are the sentinel cells of the retina, where they are involved in surveillance of tissue integrity and clearance of cellular debris. The innate immune functions of microglia are tightly controlled by retinal neurons via the secretion of suppressing factors to prevent harmful pro-inflammatory activation. Progressive retinal cell death is a common sink of all inherited retinal diseases, ...

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Translation of the abstract (German)

Mikrogliazellen erfüllen wichtige Überwachungsfunktionen in der gesunden Netzhaut und tragen wesentlich zur Aufrechterhaltung der Gewebshomöostase bei. Mikrogliale Immunmechanismen werden aktiv durch die Präsentation und Sekretion suppressiver Faktoren von retinalen Neuronen kontrolliert, um eine überschießende Mikrogliaaktivierung zu verhindern. Fortschreitender Zelltod stellt einen gemeinsamen ...

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Export bibliographical data

Item Type:Thesis of the University of Regensburg (PhD)
Date:24 May 2012
Referee:Prof. Dr. Thomas Langmann
Date of exam:21 May 2012
Institutions:Medicine > Lehrstuhl für Humangenetik
Keywords:Microglia, Netzhautdegeneration, Mikrogliaaktivierung, Mikrogliaphänotypen, Curcumin, AMWAP, Auge, neuroimmunology
Subjects:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Owner: Universitätsbibliothek Regensburg
Deposited On:24 May 2012 10:22
Last Modified:13 Mar 2014 18:52
Item ID:24477
Owner Only: item control page
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