Wendl, Christina M. and Müller, Steffen and Meier, Johannes and Fellner, Claudia and Eiglsperger, Johannes and Gosau, Martin and Prantl, Lukas and Stroszczynski , Christian and Jung, Ernst Michael (2012) High resolution contrast-enhanced ultrasound and 3-tesla dynamic contrast-enhanced magnetic resonance imaging for the preoperative characterization of cervical lymph nodes: First results. Clinical Hemorheology and Microcirculation 52 (2-4), pp. 153-166.
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The reliable detection of cervical lymph node (LN) metastases is the planning basis of a selective neck dissection for patients with oral squamous cell carcinoma (OSCC). The aim of this study was to evaluate whether contrast-enhanced ultrasound (CEUS) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) together are able to improve the preoperative characterisation of LNs. A time intensity curve analysis has been performed using CEUS and DCE-MRI for ten LNs, where one LN has been examined per patient. The studied LNs consist of five with and five without metastases. In CEUS the mean time to peak (TTP) was 18 s (range 13–29 s, standard deviation (SD) ± 7 s) for benign and 12 s (range 9–16 s, SD ± 4 s) for malignant LNs. In DCE-MRI the mean TTP was 27 s (range 18–36 s, SD ± 9 s) for benign and 21 s (range 18–27 s, SD ± 5 s) for malignant LNs. Moreover, the relative signal change with respect to reference tissue was significantly higher for LNs with than for those without metastases in both CEUS and DCE-MRI. A combination of imaging morphology, CEUS and DCE-MRI might be a promising method for a reliable differentiation of benign and malignant LNs.
|Institutions:|| Medicine > Abteilung für Unfallchirurgie|
Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie
Medicine > Lehrstuhl für Röntgendiagnostik
Physics > Institute of Theroretical Physics > Chair Professor Richter > Group Tobias Kramer
|Keywords:||CEUS, dynamic contrast-enhanced MRI, lymph node metastases|
|Subjects:||600 Technology > 610 Medical sciences Medicine|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||07 Nov 2012 11:47|
|Last Modified:||07 Nov 2012 11:47|