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Identification of the Key Residue of Calcitonin Gene Related Peptide (CGRP) 27-37 to Obtain Antagonists with Picomolar Affinity at the CGRP Receptor

Lang, Manja and De Pol, Silvia and Baldauf, Carsten and Hofmann, Hans-Jörg and Reiser, Oliver and Beck-Sickinger, Annette G. (2006) Identification of the Key Residue of Calcitonin Gene Related Peptide (CGRP) 27-37 to Obtain Antagonists with Picomolar Affinity at the CGRP Receptor. Journal of Medicinal Chemistry 49 (2), pp. 616-624.

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Other URL: http://dx.doi.org/10.1021/jm050613s


Abstract

Calcitonin gene related peptide (CGRP) plays an important role in the CNS and in the cardiovascular system. To identify high-affinity antagonists in competitive binding studies, we identified a novel radioactive tracer, [³H-propionyl-K²⁴]-hαCGRP 8-37, which was labeled in solution by a recently developed strategy using photolabile protecting groups at reactive side chains. This tracer was shown ...

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Item Type:Article
Date:26 January 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Oliver Reiser
Identification Number:
ValueType
10.1021/jm050613sDOI
Subjects:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Owner: Helge Knüttel (ADMIN)
Deposited On:05 Sep 2006
Last Modified:05 Aug 2009 13:22
Item ID:364
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