Maity, P. and König, Burkhard (2007) Enantio- and Diastereoselective Syntheses of Cyclic Cα-Tetrasubstituted α-Amino Acids and Their Use to Induce Stable Conformations in Short Peptides (Review). Pept. Sci. 90, 8 - 27.
Full text not available from this repository.
Cα-Tetrasubstituted α-amino acids are widely used to design and prepare peptides and peptide mimics with constrained conformations. Subcategories of these compounds are cyclic Cα-tetrasubstituted α-amino acids, in which both α-substituents are covalently connected. This survey presents recent advances in the synthesis and application of cyclic Cα-tetrasubstituted α-amino acids in a systematic order beginning with cyclopropane amino acids, continuing with four, five, six membered rings, and ring structures larger than six-membered. We discuss synthetic routes to the cyclic Cα-tetrasubstituted α-amino acids and their use as conformation determining elements in peptides.
|Institutions:||Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König|
|Projects:||GRK 760, Graduiertenkolleg Medizinische Chemie|
|Keywords:||artificial amino acids; cyclic compounds; synthesis; conformation|
|Subjects:||500 Science > 540 Chemistry & allied sciences|
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||05 Mar 2009 10:55|
|Last Modified:||03 Feb 2014 11:29|