Fraenzer, Juergen-Theodor and Wachs, Frank-Peter and Gleich, Otto and Licht, Anna-Katharina and Strutz, Jürgen (2006) Evaluation of vascular endothelial growth factor addition in vitro on mouse inner ear progenitor cell cultures. Neuroreport 17 (13), pp. 1369-1373.
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We analyzed progenitor cell cultures of inner ear tissue from newborn mice, and found proliferating cells, morphologically differentiating cells and subpopulations of cells expressing either neuronal or glial markers. In addition, we observed the expression of fetal liver kinase-1, a receptor for the vascular endothelial growth factor in a subpopulation of the cultured cells. Consistent with the expression of fetal liver kinase-1, addition of vascular endothelial growth factor at a dose of 10 ng/ml increased the expansion rate of inner ear-derived progenitor cells. Together with other published data, these results suggest that the vascular endothelial growth factor might be involved in inducing or supporting cochlear repair processes.
|Institutions:|| Medicine > Lehrstuhl für Neurologie|
Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde
|Subjects:||500 Science > 570 Life sciences|
500 Science > 590 Zoological sciences
600 Technology > 610 Medical sciences Medicine
|Refereed:||Yes, this version has been refereed|
|Created at the University of Regensburg:||Yes|
|Deposited On:||18 Jun 2009 14:47|
|Last Modified:||05 Aug 2009 13:57|