Deutsch
URN to cite this document: urn:nbn:de:bvb:355-opus-315
Kilger, Robert (2001) Untersuchung der Relaxation von Photofrin-generiertem Singulett-Sauerstoff in Lösungen und in vitro. PhD, Universität Regensburg
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Abstract (German)
Im Rahmen der Grundlagenforschung zur Photodynamischen Therapie wurde das Relaxationsverhalten von Photofrin-generiertem Singulett-Sauerstoff über seine Lumineszenz bei 1270 nm zeitaufgelöst untersucht, sowohl in Lösungen in Deuteriumoxid, Suspensionen von Phosphatidylcholin in Wasser und Deuteriumoxid und in Suspensionen von HT-29 Tumorzellen in Wasser und Deuteriumoxid. In wäßriger Lösung wurde eine bidirektionale Kopplung des Singulett-Zustands von Sauerstoff an den Triplett-Zustand von Photofrin nachgewiesen und theoretisch beschrieben. Die Messungen wurden ausgeführt mit einem neuartigen, hochempfindlichen Infrarot-Photomultiplier.
Translation of the abstract (English)
Within the scope of fundamentals of photodynamic therapy the relaxation behaviour of photofrin-generated singlet oxygen was investigated time resolved by its luminescence at 1270 nm, as well in solutions in deuterium oxyde as in suspensions of phosphatidylcholine in water and deuterium oxyde and in suspensions of HT-29 tumor cells in water and deuterium oxyde. In aequous solutions a coupling of the singlet state of oxygen to the triplett state of photofrin was proved and theoretically described. Measurements were carried out with a newly, high sensitive infrared multiplier.
| Item Type: | Thesis of the University of Regensburg (PhD) | ||||
|---|---|---|---|---|---|
| Referee: | Max Maier | ||||
| Date of exam: | 18 July 2001 | ||||
| Institutions: | Physics > Institute of Experimental and Applied Physics > Retired Professors > Group Ulrich Schwarz | ||||
| Classification: |
| ||||
| Keywords: | Singulettsauerstoff , Deuteriumoxid , Phosphatidylcholine , Photodynamische Therapie , Photofrin , Zellsuspension , Lipidsuspension , photofrin , cell suspension , lipid suspension | ||||
| Subjects: | 500 Science > 530 Physics | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Owner: | Universitätsbibliothek Regensburg | ||||
| Deposited On: | 21 Oct 2009 12:45 | ||||
| Last Modified: | 09 Oct 2012 09:22 | ||||
| Item ID: | 9876 |
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