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Analysen zum transformierenden Potenzial des E4orf3-Proteins von Adenovirus Serotyp 5

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Täuber, Birgitt
Date of publication of this fulltext: 12 Jun 2003 13:07

Abstract (German)

Die in der vorliegenden Arbeit dargestellten Untersuchungen zum transformierenden Potenzial humaner Adenoviren zeigen erstmals, dass zwei virale Genprodukte der frühen Region 4 - E4orf3 und E4orf6 - von Adenovirus Serotyp 5 transformierende Eigenschaften aufweisen, die zur 'Hit & Run'-Transformation primärer BRK-Zellen beitragen. Den onkogenen Aktivitäten beider E4-Proteine liegen mutagene ...


Translation of the abstract (English)

The transforming potential of human adenoviruses has been traditionally ascribed to the E1A and E1B transcription units encoded within early region 1 (E1). These gene products are sufficient to initiate complete cell transformation by virtue of their ability to interact with and manipulate the functions of several growth-regulatory proteins that control cell cycle progression and programmed cell ...


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