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Lack of correlation between the vitamin D receptor Fokl start codon polymorphism and bone mineral density in patients with Crohn's disease

Bregenzer, N. ; Schäffler, A. ; Gelbmann, C. M. ; Steinkamp, M. ; Reinshagen, M. ; Schölmerich, J. ; Andus, T.



Abstract

INTRODUCTION: We have examined the association of bone mineral density of patients with inflammatory bowel disease with a polymorphism in the gene encoding the vitamin D receptor. The thymine/cytosine (T/C) polymorphism in the first of two start codons can be defined by a restriction fragment length polymorphism using the restriction endonuclease FokI. Vitamin D receptor alleles containing the ...

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