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Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships

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Salmen, Sunnhild
Date of publication of this fulltext: 21 Jan 2004 15:32

Abstract (English)

The role and the importance of hyaluronic acid and hyaluronidases in physiological and pathophysiological processes are largely misunderstood, so that selective and potent hyaluronidase inhibitors are required. As such compounds are not known so far, the goal of this project was to identify and to synthesise lead-like compounds, to optimise the structures and to study the structure-activity ...


Translation of the abstract (German)

Die (patho)physiologische Rolle von Hyaluronsäure und deren Abbauprodukte sowie der Hyaluronidasen ist weitgehend unverstanden, u. a. weil bisher keine potenten und selektiven Hyaluronidase-Inhibitoren zur Verfügung stehen. Das Ziel der Dissertationsarbeit war die Identifizierung und die Synthese von Leitstrukturen, ihre Optimierung sowie die Erstellung von Struktur-Wirkungs-Beziehungen. ...


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