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Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships

Salmen, Sunnhild (2004) Inhibitors of bacterial and mammalian hyaluronidase - Synthesis and structure-activity relationships. PhD, Universität Regensburg.

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Date of publication of this fulltext: 21 Jan 2004 15:32

Abstract (English)

The role and the importance of hyaluronic acid and hyaluronidases in physiological and pathophysiological processes are largely misunderstood, so that selective and potent hyaluronidase inhibitors are required. As such compounds are not known so far, the goal of this project was to identify and to synthesise lead-like compounds, to optimise the structures and to study the structure-activity ...


Translation of the abstract (German)

Die (patho)physiologische Rolle von Hyaluronsäure und deren Abbauprodukte sowie der Hyaluronidasen ist weitgehend unverstanden, u. a. weil bisher keine potenten und selektiven Hyaluronidase-Inhibitoren zur Verfügung stehen. Das Ziel der Dissertationsarbeit war die Identifizierung und die Synthese von Leitstrukturen, ihre Optimierung sowie die Erstellung von Struktur-Wirkungs-Beziehungen. ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:20 January 2004
Referee:Prof. Dr. Armin Buschauer
Date of exam:21 November 2003
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Hyaluronsäure , Hyaluronidasen , Enzyminhibitor , Chemische Synthese , Pharmacologie , Struktur-Wirkungs-Beziehungen , Hyaluronic acid , Hyaluronidase , Synhtesis , SAR , Enzyme Inhibitor
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10160
Owner only: item control page


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