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Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor

Hubensack, Martina (2005) Approaches to overcome the blood-brain barrier in the chemotherapy of primary and secondary brain tumors: Modulation of P-glycoprotein 170 and targeting of the transferrin receptor. PhD, Universität Regensburg.

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Date of publication of this fulltext: 14 Mar 2005 06:58

Abstract (English)

Chemotherapy of primary and secondary brain tumors is hampered by the existence of the blood-brain-barrier (BBB) which reduce the brain concentrations of lipophilic cytostatic agents by efflux transport proteins like p-glycoprotein 170 (p-gp). Combining cytostatic agents that are p-gp substrates with inhibitors of p-gp like valspodar is a new approach to overcome the BBB. As a model of non-small ...

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Translation of the abstract (German)

Die Behandlung von primären und sekundären Hirntumoren mittels Chemotherapie ist durch die Blut-Hirn-Schranke (BHS) erschwert, da die BHS die Hirnkonzentrationen lipophiler Zytostatika mit Hilfe von Effluxtransportern wie dem P-glykoprotein 170 (P-gp) reduziert. Die Kombination von Zytostatika, die Substrate des P-gps sind, mit P-gp-Inhibitoren wie Valspodar ist ein neuer Ansatz zur Überwindung ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:13 March 2005
Referee:Prof. Dr. Armin Buschauer
Date of exam:15 February 2005
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Blut-Hirn-Schranke , ABC-Transporter , PGP , Taxol , Transferrinrezeptor , Targeted drug delivery , Hirntumor , Hirnmetastase , Multidrug-Resistenz , Calcein-AM, ABCG2 , Lungentumore , Elacridar , Tariquidar , calcein-AM , ABCG2 , lung cancer , elacridar , tariquidar
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10297
Owner only: item control page

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