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Characterisation of bovine testicular hyaluronidase and a hyaluronate lyase from Streptococcus agalactiae. Investigations on the effect of pH on hyaluronan degradation and preclinical studies on the adjuvant administration of the enzymes in cancer chemotherapy

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Hoechstetter, Julia
Date of publication of this fulltext: 02 Aug 2005 07:00

Abstract (English)

Pharmaceutical preparations of bovine testicular hyaluronidase (BTH) have been therapeutically applied in several medical fields for many years. In the context with the risk of BSE, companies stopped the production of BTH preparations resulting in a shortage of this drug, which is the only highly effective antidote in the treatment of extravasations of vinca alkaloids. To find a substitute for ...


Translation of the abstract (German)

Arzneimittel mit boviner testikulärer Hyaluronidase (BTH) als wirksamer Bestandteil wurden therapeutisch erfolgreich eingesetzt. Wegen der TSE-Problematik wurde die Produktion dieser Medikamente eingestellt, so dass es, trotz großer Nachfrage, insbesondere als hochwirksames Antidot bei Paravasaten (Vincaalkaloide), zu einem Engpass an BTH-Präparaten kam. Obwohl BTH-Präparate in der Klinik lange ...


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