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Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis

Maa Bared, Salim (2005) Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis. PhD, Universität Regensburg.

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Date of publication of this fulltext: 27 Oct 2005 07:01

Abstract (English)

The ATP-binding cassette transporter 1 (ABCA1) has recently been identified as a major regulator of systemic HDL. The main focus of this work was to identify and further characterize ABCA1-interactive proteins. A Yeast-Two-Hybrid screening with the last 144 amino acids of the ABCA1 C-terminus as bait was performed. Our results indicate that ABCA1 forms a heteromeric complex with each of: ...


Translation of the abstract (German)

Vor kurzem wurde die regulatorische Funktion des ATP-bindenden Kassettentransporters 1 (ABCA1) auf das Plasma HDL-Cholesterin identifiziert. Das Hauptanliegen dieser Dissertation war es, ABCA1-Interaktive Proteine zu identifizieren und zu charakterisieren. Dazu wurde ein Yeast-Two-Hybrid Experiment durchgeführt, wobei die letzten 144 Aminosäuren des ABCA1-C-Terminus als Köder benutzt wurden. Die ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:26 October 2005
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. G. Schmitz
Date of exam:17 October 2005
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Arteriosklerose , Differentielle Genexpression , Phagozytose , Fluoreszenz Mikroskopie , Protein-Protein Interaktion , ABCA1 , Syntaxin 13 , beta2-syntrophin , Affymetrix gene chips
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10341
Owner only: item control page


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