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Identification and characterization of ABCA1-interactive proteins and their relevance to atherosclerosis

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Maa Bared, Salim
Date of publication of this fulltext: 27 Oct 2005 07:01

Abstract (English)

The ATP-binding cassette transporter 1 (ABCA1) has recently been identified as a major regulator of systemic HDL. The main focus of this work was to identify and further characterize ABCA1-interactive proteins. A Yeast-Two-Hybrid screening with the last 144 amino acids of the ABCA1 C-terminus as bait was performed. Our results indicate that ABCA1 forms a heteromeric complex with each of: ...


Translation of the abstract (German)

Vor kurzem wurde die regulatorische Funktion des ATP-bindenden Kassettentransporters 1 (ABCA1) auf das Plasma HDL-Cholesterin identifiziert. Das Hauptanliegen dieser Dissertation war es, ABCA1-Interaktive Proteine zu identifizieren und zu charakterisieren. Dazu wurde ein Yeast-Two-Hybrid Experiment durchgeführt, wobei die letzten 144 Aminosäuren des ABCA1-C-Terminus als Köder benutzt wurden. Die ...


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