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New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships

Braun, Stephan (2006) New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Feb 2006 07:40

Abstract (English)

Potent and selective inhibitors of hyaluronidases are not reported in the literature so far. Such compounds are required as pharmacological tools to investigate the physiological and pathophysiological role of the enzymes and their preferred substrate, hyaluronic acid. Moreover, such inhibitors might be of therapeutic value, e.g. in the treatment of arthrosis, as new anti-fertility agents or as ...


Translation of the abstract (German)

Potente, selektive Inhibitoren von Hyaluronidasen sind bislang nicht in der Literatur bechrieben. Solche Substanzen werden als pharmakologische Werkzeuge benötigt, um die (patho)physiologische Rolle der Hyaluronidasen und ihres Substrats, der Hyaluronsäure, zu untersuchen. Darüber hinaus könnten Hyaluronidase-Inhibitoren als Arzneistoffe interessant sein, z.B. zur Behandlung von Arthrosen, als ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:23 February 2006
Referee:Prof. Dr. Armin Buschauer
Date of exam:10 October 2005
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Inhibitor , Hyaluronidasen , Struktur-Aktivitäts-Beziehung , Vitamin C-Derivate , Benzoxazol-2-thion , Inhibitor , hyaluronidase , Vitamin C derivatives , benzoxazole-2-thione
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10385
Owner only: item control page


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