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New inhibitors of bacterial hyaluronidase - synthesis and structure-activity relationships

URN to cite this document:
urn:nbn:de:bvb:355-opus-5856
Braun, Stephan
Date of publication of this fulltext: 24 Feb 2006 07:40


Abstract (English)

Potent and selective inhibitors of hyaluronidases are not reported in the literature so far. Such compounds are required as pharmacological tools to investigate the physiological and pathophysiological role of the enzymes and their preferred substrate, hyaluronic acid. Moreover, such inhibitors might be of therapeutic value, e.g. in the treatment of arthrosis, as new anti-fertility agents or as ...

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Translation of the abstract (German)

Potente, selektive Inhibitoren von Hyaluronidasen sind bislang nicht in der Literatur bechrieben. Solche Substanzen werden als pharmakologische Werkzeuge benötigt, um die (patho)physiologische Rolle der Hyaluronidasen und ihres Substrats, der Hyaluronsäure, zu untersuchen. Darüber hinaus könnten Hyaluronidase-Inhibitoren als Arzneistoffe interessant sein, z.B. zur Behandlung von Arthrosen, als ...

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