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Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation

Zimmermann, Jochen (2006) Furan- and pyran-based heterocycles as subtype-selective ligands of the estrogen receptor. Synthesis and biological characterisation. PhD, Universität Regensburg.

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Date of publication of this fulltext: 04 Jul 2006 07:40

Abstract (English)

The discovery of an estrogen binding protein in target tissues about 50 years ago provided a rational basis for the endocrine therapy of breast cancer. After the approval of tamoxifen as drug for treatment of hormone-dependent mammary carcinomas antiestrogen therapy has become an established treatment modality for this malignancy. More recently an isoform of the estrogen receptor was discovered ...

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Translation of the abstract (German)

Als man vor etwa 50 Jahren ein Protein entdeckte, welches Estrogene zu binden vermag, bot sich ein vielversprechender Ansatz für die endokrine Therapie von Bruskrebs. Nach der Freigabe von Tamoxifen als Wirkstoff zur Behandlung des hormonabhängigen Mammakarzinoms hat sich die Therapie mit Antiestrogenen als Behandlungsmethode für Brustkrebs etabliert. Vor Kurzem wurde ein zweiter Estrogen ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:3 July 2006
Referee:Prof. Dr. Erwin von Angerer
Date of exam:4 October 2005
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Antiöstrogene , Brustkrebs , Östrogenrezeptor , Furanderivate , Pyranderivate , Heterocyclische Verbindungen , Ligand <Biochemie> , Antiestrogene , Estrogen Rezeptor , Hormon-abhängiger Brustkrebs , Endokrine Therapie , Diphenylfuran , Antiestrogens , Estrogen receptor , Hormone-dependent brest cancer , Endocrine therapy , Diphenylfuran
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10393
Owner only: item control page

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