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Arpromidine-related acylguanidines: synthesis and structure-activity relationships of a new class of guanidine-type histamine H2 receptor agonists with reduced basicity

URN to cite this document:
urn:nbn:de:bvb:355-opus-5617
Ghorai, Prasanta
Date of publication of this fulltext: 06 Oct 2006 07:41


Abstract (English)

There has been increasing evidence that histamine receptor stimulation might be an interesting aspect for the development of future drugs as well. Arpromidine and related imidazolylpropylguanidines are the most potent H2R agonists on the isolated guinea pig right atrium. The strongly basic guanidino group is essential for the agonistic activity but it is also responsible for very low oral ...

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Translation of the abstract (German)

Das Interesse an Histamin-H2-Rezeptoragonisten als potentiellen Arzneistoffen und pharmakologischen Werkzeugen nimmt u. a. wegen der Induktion der Zelldifferenzierung von Leukämiezellen sowie wegen der möglichen neuropharmakologischen Wirkung zu. Die in unserer Arbeitsgruppe ursprünglich zur Behandlung schwerer Formen der Herzinsuffizienz entwickelten Imidazolylpropylguanidine vom Typ des ...

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