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New guanidinium compounds for the molecular recognition of carboxylates and contributions to the synthesis of bivalent NPY Y1 receptor antagonists

Suhs, Thomas (2007) New guanidinium compounds for the molecular recognition of carboxylates and contributions to the synthesis of bivalent NPY Y1 receptor antagonists. PhD, Universität Regensburg.

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Date of publication of this fulltext: 06 Mar 2007 08:10

Abstract (English)

The chemical properties of the guanidinium group as well as its ability to form H-bonds, charge pairing and cation-π interactions opens up a large number of possibilities in molecular recognition and pharmaceutical chemistry. In the first chapter, the synthesis of Artificial Ethoxycarbonyl Guanidinium Amino Acids is reported. Carboxy� and amino-groups can be selectively deprotected, but ...

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Translation of the abstract (German)

Im ersten Kapitel der Arbeit wird die Synthese von Ethoxycarbonyl Guanidinium Aminosäuren beschrieben. Carboxy- und Aminoende können durch geeignete Methoden weiter funktionalisiert werden. Die Ethoxycarbonylgruppe kann enzymatisch mittels einer Esterase (E.C. 3.1.1.1) abgespalten werden. Die Bindungseigenschaften gegenüber Carboxylaten wurden mittels NMR-Titrationen untersucht. In weiteren ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:5 March 2007
Referee:Burkhard (Prof. Dr.) König
Date of exam:24 March 2006
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Keywords:Molekulare Erkennung , Neuropeptid Y , Carboxylate , Supramolekulare Chemie , Fluoreszenzspektroskopie , Guanidiniumverbindungen , Carbonylverbindungen , Ethoxygruppe , Chemische Synthese , Chemische Bindung , NMR-Spektroskopie , Titration , Fluorophore , , Molecular recognition , Guanidines , NPY Y1 antagonists , fluorescence titrations , synthesis of guanidines
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10492
Owner only: item control page

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