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New guanidinium compounds for the molecular recognition of carboxylates and contributions to the synthesis of bivalent NPY Y1 receptor antagonists

URN to cite this document:
urn:nbn:de:bvb:355-opus-6428
DOI to cite this document:
10.5283/epub.10492
Suhs, Thomas
Date of publication of this fulltext: 06 Mar 2007 08:10


Abstract (English)

The chemical properties of the guanidinium group as well as its ability to form H-bonds, charge pairing and cation-π interactions opens up a large number of possibilities in molecular recognition and pharmaceutical chemistry. In the first chapter, the synthesis of Artificial Ethoxycarbonyl Guanidinium Amino Acids is reported. Carboxy� and amino-groups can be selectively deprotected, but ...

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Translation of the abstract (German)

Im ersten Kapitel der Arbeit wird die Synthese von Ethoxycarbonyl Guanidinium Aminosäuren beschrieben. Carboxy- und Aminoende können durch geeignete Methoden weiter funktionalisiert werden. Die Ethoxycarbonylgruppe kann enzymatisch mittels einer Esterase (E.C. 3.1.1.1) abgespalten werden. Die Bindungseigenschaften gegenüber Carboxylaten wurden mittels NMR-Titrationen untersucht. In weiteren ...

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