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ABCA transporters and associated genes in lipid metabolism

URN to cite this document:
urn:nbn:de:bvb:355-opus-7917
Sigrüner, Alexander
Date of publication of this fulltext: 13 Dec 2007 11:55


Abstract (English)

The ATP-binding cassette transporters A1 (ABCA1) and A7 (ABCA7) are inversely regulated under loading and deloading conditions and we were interested in protein/protein interactions of these transporters. The main topic was to identify, verify and characterize these interactions. In case of ABCA7, the yeast two-hybrid approach led to false positive results, and therefore we focused on the ...

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Translation of the abstract (German)

Die ABC Transporter A1 (ABCA1) und A7 (ABCA7) werden durch Be- und Entladung entgegengesetzt reguliert und unser Interesse galt ihren Protein/Protein Interaktionen. Im Fokus meiner Dissertation war die Identifikation, Bestätigung und Charakterisierung dieser Interaktionen. Im Falle von ABCA7 führte der Hefe Two-Hybrid Ansatz zu falsch positiven Ergebnissen die nicht weiter verfolgt wurden. ...

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