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Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues

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Svobodová, Jaroslava
Date of publication of this fulltext: 26 Jun 2007 12:00

Abstract (English)

The Dissertation deals with the synthesis and characterization of Id3 which is the smallest member of the Id protein family. It is a negative regulator of the bHLH transcription factors; by the formation of heterodimers with the bHLH proteins, Id3 prevents their binding to DNA and hence the transcriptional activation. This eventually leads to increased cell proliferation and reduced cell ...


Translation of the abstract (German)

Die Dissertation behandelt die Synthese und Charakterisierung von Id3, welches das kleinste Mitglied der Id-Protein Familie ist. bHLH-Transkriptionsfaktoren werden negativ reguliert: durch Bildung von Heterodimeren mit diesen bHLH-Proteinen verhindert Id3 ihre Bindung an die DNA und demzufolge die Aktivierung der Transkription. Letztendlich führt dies zu zunehmender Zell-Proliferation und ...


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