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Id3, inhibitor of DNA binding and cell differentiation: synthesis and conformational analysis of the full-length protein and its truncated analogues

URN to cite this document:
urn:nbn:de:bvb:355-opus-8133
Svobodová, Jaroslava
Date of publication of this fulltext: 26 Jun 2007 12:00


Abstract (English)

The Dissertation deals with the synthesis and characterization of Id3 which is the smallest member of the Id protein family. It is a negative regulator of the bHLH transcription factors; by the formation of heterodimers with the bHLH proteins, Id3 prevents their binding to DNA and hence the transcriptional activation. This eventually leads to increased cell proliferation and reduced cell ...

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Translation of the abstract (German)

Die Dissertation behandelt die Synthese und Charakterisierung von Id3, welches das kleinste Mitglied der Id-Protein Familie ist. bHLH-Transkriptionsfaktoren werden negativ reguliert: durch Bildung von Heterodimeren mit diesen bHLH-Proteinen verhindert Id3 ihre Bindung an die DNA und demzufolge die Aktivierung der Transkription. Letztendlich führt dies zu zunehmender Zell-Proliferation und ...

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