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In vivo Analyse der Chromatinstruktur ribosomaler DNA in S. cerevisiae

URN to cite this document:
urn:nbn:de:bvb:355-opus-8512
Merz, Katharina
Date of publication of this fulltext: 14 Jul 2008 16:16


Abstract (German)

Das Ziel dieser Arbeit bestand darin, die Komposition und Struktur ribosomalen Chromatins von S. cerevisiae in vivo zu untersuchen. In einer logarithmisch wachsenden Hefezelle wird etwa die Hälfte der ~150 rRNA Gene aktiv von der RNA Polymerase I (Pol I) transkribiert (offene Chromatinform), die andere Hälfte ist inaktiv und nukleosomal organisiert (geschlossene Chromatinform). Die Ergebnisse ...

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Translation of the abstract (English)

In a single yeast cell there are approximately 150 rDNA gene copies arranged in a head to tail configuration on chromosome XII. During logarithmic growth only about half of the rDNA genes are actively transcribed by RNA Polymerase I whereas the other half is silenced. Results from Psoralen crosslinking experiments and electron microscopy studies have suggested that special chromatin structures ...

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