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Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes

URN to cite this document:
urn:nbn:de:bvb:355-opus-9037
Spickenreither, Martin
Date of publication of this fulltext: 09 Jan 2008 16:19


Abstract (English)

There is a need for hyaluronidase inhibitors as pharmacological tools to study the (patho)physiological role of these enzymes. As such compounds could also be useful as drugs, e.g. in the treatment of (bacterial) infections, arthroses and cancer or as contraceptives, the goal of this thesis was the synthesis, identification and structural optimization of low molecular weight inhibitors. The ...

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Translation of the abstract (German)

Selektive Hyaluronidase-Inhibitoren werden als pharmakologische Werkzeuge benötigt, um die (patho)physiologische Rolle dieser Enzyme zu untersuchen. Zudem könnten solche Verbindungen auch als Wirkstoffe z.B. bei (bakteriellen) Infektionen, Arthrosen und Krebs eingesetzt werden oder als Kontrazeptiva dienen. Ziel dieser Arbeit war die Synthese, Identifikation und Strukturoptimierung von ...

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