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Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes

Spickenreither, Martin (2008) Inhibitors of bacterial and mammalian hyaluronidases: design, synthesis and structure-activity relationships with focus on human enzymes. PhD, Universität Regensburg.

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Date of publication of this fulltext: 09 Jan 2008 16:19

Abstract (English)

There is a need for hyaluronidase inhibitors as pharmacological tools to study the (patho)physiological role of these enzymes. As such compounds could also be useful as drugs, e.g. in the treatment of (bacterial) infections, arthroses and cancer or as contraceptives, the goal of this thesis was the synthesis, identification and structural optimization of low molecular weight inhibitors. The ...

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Translation of the abstract (German)

Selektive Hyaluronidase-Inhibitoren werden als pharmakologische Werkzeuge benötigt, um die (patho)physiologische Rolle dieser Enzyme zu untersuchen. Zudem könnten solche Verbindungen auch als Wirkstoffe z.B. bei (bakteriellen) Infektionen, Arthrosen und Krebs eingesetzt werden oder als Kontrazeptiva dienen. Ziel dieser Arbeit war die Synthese, Identifikation und Strukturoptimierung von ...

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Export bibliographical data



Item type:Thesis of the University of Regensburg (PhD)
Date:8 January 2008
Referee:Prof. Dr. Armin Buschauer
Date of exam:14 December 2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Classification:
NotationType
81.20.KaPACS
87.14.ejPACS
Keywords:Enzyminhibitor , Struktur-Aktivitäts-Beziehung , Hyaluronsäure , Rekombinantes Protein , Hyaluronidasen , Vitamin C-Derivate , Hyal-1 , PH-20 , bovine testikuläre Hyaluronidase , ascorbic acid derivatives , indole-3-butyric acid , glucurono-6,3-lactone , hyaluronate lyase
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10693
Owner only: item control page

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