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Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships

URN to cite this document:
urn:nbn:de:bvb:355-opus-9041
Kraus, Anja
Date of publication of this fulltext: 24 Jan 2008 16:19


Abstract (English)

Potent and selective histamine H2 receptor (H2R) agonists are valuable pharmacological tools and might be of therapeutic value as drugs, for example in the treatment of severe congestive heart failure. At the beginning of this project arpromidine and related N-[3-(1H-imidazol-4-yl)propyl]guanidines were known as the most potent H2R agonists. Previous studies from our group have shown that the ...

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Translation of the abstract (German)

Potente und selektive Histamin H2-Rezeptor (H2R) Agonisten sind wertvolle pharmakologische Werkzeuge und sie könnten therapeutische Verwendung finden, z. B. zur Therapie der Herzinsuffizienz. Zu Beginn des Projekts waren Arpromidin und entsprechende N-[3-(1H-Imidazol-4-yl)propyl]guanidine als die potentesten H2R-Agonisten bekannt. Vorausgegangene Untersuchungen unserer Arbeitsgruppe zeigten, dass ...

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