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Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships

Kraus, Anja (2008) Highly potent, selective acylguanidine-type histamine H2 receptor agonists: synthesis and structure-activity relationships. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Jan 2008 16:19

Abstract (English)

Potent and selective histamine H2 receptor (H2R) agonists are valuable pharmacological tools and might be of therapeutic value as drugs, for example in the treatment of severe congestive heart failure. At the beginning of this project arpromidine and related N-[3-(1H-imidazol-4-yl)propyl]guanidines were known as the most potent H2R agonists. Previous studies from our group have shown that the ...

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Translation of the abstract (German)

Potente und selektive Histamin H2-Rezeptor (H2R) Agonisten sind wertvolle pharmakologische Werkzeuge und sie könnten therapeutische Verwendung finden, z. B. zur Therapie der Herzinsuffizienz. Zu Beginn des Projekts waren Arpromidin und entsprechende N-[3-(1H-Imidazol-4-yl)propyl]guanidine als die potentesten H2R-Agonisten bekannt. Vorausgegangene Untersuchungen unserer Arbeitsgruppe zeigten, dass ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:23 January 2008
Referee:Prof. Dr. Armin Buschauer
Date of exam:14 December 2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Histamin , Histaminrezeptor , Guanidin , Guanidinderivate , Agonist , Chemische Synthese , Struktur-Aktivitäts-Beziehung , Imidazol , Aminothiazol , Bivalente Liganden , GTPase-Assay , imidazole , aminothiazole , bivalent ligands , GTPase assay
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10699
Owner only: item control page

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