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Intra- and intercellular trafficking of the prion protein

Schiff, Edwin (2008) Intra- and intercellular trafficking of the prion protein. PhD, Universität Regensburg.

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Date of publication of this fulltext: 16 Apr 2008 16:20

Abstract (English)

Transmissible spongiform encephalopathies (TSEs) consist of a group of diseases of infectious, sporadic and genetic origin, found in higher organisms and caused by the pathological form of the prion protein (PrPSc). The inheritable subgroup of TSEs are linked to deleterious changes in the prion gene prnp, which favour its misfolding and are passed on to offspring in an autosomal-dominant fashion. ...

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Translation of the abstract (German)

Transmissible spongiforme enzephalopathien (TSEs) ist eine Gruppe von tierischen Krankheiten mit infektiöser, sporadischer oder genetischer Ätiologie, die durch die pathologisch-missgefaltete Form des PrP-Proteins (Prion oder PrPSc) ausgelöst werden. Mutationen im prnp-Gen, welche die Missfaltung des Proteins begünstigen, bilden die Untergruppe der vererbbaren Erkrankungen. Diese Krankheiten ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:15 April 2008
Referee:Daniela (Prof. Dr.); Zurzolo Männel
Date of exam:10 December 2007
Institutions:Medicine > Lehrstuhl für Immunologie
Biology, Preclinical Medicine
Keywords:Prionprotein , Nervenzelle , Dendritische Zelle , Lipidmembran , Proteintransport , Zentralnervensystem , PrPC , PrPSc , lipid rafts , PrPC , PrPSc , lipid rafts , tunneling nanotubes , dendritic cell , neuron
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:10719
Owner only: item control page

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