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Cellular role of the putative Ca2+-dependent Cl- channel bestrophin

URN to cite this document:
urn:nbn:de:bvb:355-opus-10217
Barro Soria, René
Date of publication of this fulltext: 24 Jul 2008 16:28


Abstract (English)

Ca2+-activated Cl- channels (CaCCs) participate in a variety of important physiological processes such as transepithelial transport, olfactory and taste transduction, neuronal and cardiac excitability, fototransduction and fertility. These Cl- channels also play a key role in diseases such as cystic fibrosis, and polycystic kidney disease. Although epithelial CaCCs have been studied for more than ...

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Translation of the abstract (German)

Ca2+-aktivierbare Cl--Kanäle (CaCCs) sind an einer Vielzahl wichtiger physiologischer Prozesse beteiligt, wie z.B. transepithelialem Transport, Weiterleitung von Geruchs- und Geschmacksreizen, neuronaler und kardialer Erregbarkeit und Fototransduktion. Diese Cl- Kanäle spielen ebenso eine Rolle bei Krankheiten wie der Mukoviszidose und der polyzystischen Nierenerkrankung. Obwohl epitheliale CaCCs ...

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