| Item type: | Article | ||||||||||||||||||||||
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| Journal or Publication Title: | Journal of Molecular Microbiology and Biotechnology | ||||||||||||||||||||||
| Publisher: | Karger | ||||||||||||||||||||||
| Volume: | 4 | ||||||||||||||||||||||
| Number of Issue or Book Chapter: | 4 | ||||||||||||||||||||||
| Page Range: | pp. 453-461 | ||||||||||||||||||||||
| Date: | 2002 | ||||||||||||||||||||||
| Institutions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl | ||||||||||||||||||||||
| Identification Number: |
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| Classification: |
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| Keywords: | Archaea/*genetics Bacteria/classification/*genetics Gene Transfer Techniques *Genome, Archaeal Methanosarcina/classification/*genetics/metabolism Open Reading Frames Phylogeny Support, Non-U.S. Gov't | ||||||||||||||||||||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences | ||||||||||||||||||||||
| Status: | Published | ||||||||||||||||||||||
| Refereed: | Yes, this version has been refereed | ||||||||||||||||||||||
| Created at the University of Regensburg: | No | ||||||||||||||||||||||
| Item ID: | 10904 |
Abstract
The Archaeon Methanosarcina mazei and related species are of great ecological importance as they are the only organisms fermenting acetate, methylamines and methanol to methane, carbon dioxide and ammonia (in case of methylamines). Since acetate is the precursor of 60% of the methane produced on earth these organisms contribute significantly to the production of this greenhouse gas, e.g. in rice ...
Abstract
The Archaeon Methanosarcina mazei and related species are of great ecological importance as they are the only organisms fermenting acetate, methylamines and methanol to methane, carbon dioxide and ammonia (in case of methylamines). Since acetate is the precursor of 60% of the methane produced on earth these organisms contribute significantly to the production of this greenhouse gas, e.g. in rice paddies. The 4,096,345 base pairs circular chromosome of M. mazei is more than twice as large as the genomes of the methanogenic Archaea currently completely sequenced (Bult et al., 1996; Smith et al., 1997). 3,371 open reading frames (ORFs) were identified. Based on currently available sequence data 376 of these ORFs are Methanosarcina-specific and 1,043 ORFs find their closest homologue in the bacterial domain. 544 of these ORFs reach significant similarity values only in the bacterial domain. They include 56 of the 102 transposases, and proteins involved in gluconeogenesis, proline biosynthesis, transport processes, DNA-repair, environmental sensing, gene regulation, and stress response. Striking examples are the occurrence of the bacterial GroEL/GroES chaperone system and the presence of tetrahydrofolate-dependent enzymes. These findings might indicate that lateral gene transfer has played an important evolutionary role in forging the physiology of this metabolically versatile methanogen.
Metadata last modified: 24 May 2018 11:42
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