Statistical evidence for a biochemical pathway of natural, sequence-targeted G/C to C/G transversion mutagenesis in Haemophilus influenzae Rd

URN to cite this document:: urn:nbn:de:bvb:355-epub-109253
DOI to cite this document:: 10.5283/epub.10925

Merkl, Rainer ; Fritz, Hans Joachim

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Date of publication of this fulltext: 16 Nov 2009 08:23

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Abstract

Markov chain analysis of the Haemophilus influenzae Rd genome reveals striking under-representation of three palindromic tetranucleotide strings (CCGG, GGCC and CATG), accompanied by over-representation of six tetranucleotide strings that are derived from the former by exchanging strand location of the two residues making up a G/C nucleotide pair at the terminal palindrome position. Constraints ...