Induction of Raf kinase inhibitor protein contributes to macrophage differentiation

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1099

Schuierer, Marion M. ; Heilmeier, Ursula ; Boettcher, Alfred ; Ugocsai, Peter ; Bosserhoff, Anja K. ; Schmitz, Gerd ; Langmann, Thomas

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:25

Alternative Links zum Volltext:Pubmed DOI Verlag

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Zusammenfassung

Differential gene expression analysis of human blood monocytes has identified the Raf kinase inhibitor protein (RKIP) as a continuously upregulated gene in macrophage and dendritic cell maturation. Using realtime RT-PCR and Western blot analysis we were able to confirm the initial DNA-microarray findings of RKIP induction on mRNA and protein levels. RKIP upregulation in primary cells and ...