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Stimulation of Vgamma9/Vdelta2 T lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate

Amslinger, Sabine ; Hecht, Stefan ; Rohdich, Felix ; Eisenreich, Wolfgang ; Adam, Petra ; Bacher, Adelbert ; Bauer, Stefan



Abstract

(E)-1-Hydroxy-2-methyl-but-2-enyl 4-diphosphate, a recently discovered intermediate in the deoxyxylulose phosphate pathway of isoprenoid biosynthesis, has been shown to act as a potent immunomodulator. In cultures of human peripheral blood mononuclear cells from eight non-related donors, the compound stimulated the proliferation of Vγ9/Vδ2 T lymphocytes with a median EC50 of 70 pM when 10 U/ml of ...

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