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Synthesis of a biotinated amphiphile

Amslinger, S., Hirsch, A. and Hampel, F. (2004) Synthesis of a biotinated amphiphile. Tetrahedron 60 (50), pp. 11565-11569.

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The synthesis of a biotinated amphiphile assembled from D-(+)-biotin, ethylene diamine as spacer, galactaric acid and 1-dodecylamine was achieved in six steps. The key step was the synthesis of a bisacetonide protected galactaric ester, the structure of which was determined by X-ray analysis. Aminolysis, spacer attachment, coupling with biotin and deprotection led to the amphiphilic galactaramide. (C) 2004 Published by Elsevier Ltd.

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Item type:Article
Additional Information (public):Times Cited: 0
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ISI:000225148000028Web of Science ID
Keywords:D-(+)-biotin amphiphile galactaric acid carbohydrate derivatives Derivatives nmr
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:11063
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