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A photoactivated diazopyruvoyl cross-linking agent for bonding tissue containing type-I collagen

Givens, R. S. ; Timberlake, G. T. ; Conrad, P. G. ; Yousef, A. L. ; Weber, J. F. ; Amslinger, S.


On the basis of the earlier examples of diazopyruvoyl (DAP) groups reported by Lawton for covalent binding and cross-linking of proteins and oligopeptides and our recent demonstration that a coumaryl diazopyruvamide was used to label Type-l collagen, we have extended our investigations to the synthesis and cross-linking capabilities of a bis-DAP polyethylene glycol to cross-link Type-I collagen. ...


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