Hecht, S. ; Amslinger, S. ; Jauch, J. ; Kis, K. ; Trentinaglia, V. ; Adam, P. ; Eisenreich, W. ; Bacher, A. ; Rohdich, F.
Alternative Links zum Volltext:WebofscienceDOI
Dokumentenart: | Artikel |
---|
Titel eines Journals oder einer Zeitschrift: | Tetrahedron Lett. |
---|
Verlag: | Elsevier |
---|
Band: | 43 |
---|
Nummer des Zeitschriftenheftes oder des Kapitels: | 49 |
---|
Seitenbereich: | S. 8929-8933 |
---|
Datum: | 2002 |
---|
Zusätzliche Informationen (Öffentlich): | Times Cited: 10 |
---|
Institutionen: | Chemie und Pharmazie > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger |
---|
Identifikationsnummer: | Wert | Typ |
---|
ISI:000179238400030 | Web of Science | 10.1016/S0040-4039(02)02195-0 | DOI |
|
---|
Stichwörter / Keywords: | Escherichia-coli
precursor
thiamin
d-1-deoxyxylulose
5-phosphate
pyridoxol
thiazole |
---|
Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
---|
Status: | Veröffentlicht |
---|
Begutachtet: | Ja, diese Version wurde begutachtet |
---|
An der Universität Regensburg entstanden: | Nein |
---|
Dokumenten-ID: | 11073 |
---|
Zusammenfassung
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-H-3]-6 and [1-H-2(1)]-6 from the same starting material in four steps where the hydrogen isotope is ...
Zusammenfassung
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-H-3]-6 and [1-H-2(1)]-6 from the same starting material in four steps where the hydrogen isotope is introduced in the last reaction step from deuterated or tritiated sodium borohydride. The radiochemical yield of [1-H-3]-6 was 15%. (C) 2002 Elsevier Science Ltd. All rights reserved.