Hecht, S. ; Amslinger, S. ; Jauch, J. ; Kis, K. ; Trentinaglia, V. ; Adam, P. ; Eisenreich, W. ; Bacher, A. ; Rohdich, F.
Alternative Links zum Volltext:WebofscienceDOI
| Dokumentenart: | Artikel |
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| Titel eines Journals oder einer Zeitschrift: | Tetrahedron Lett. |
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| Verlag: | Elsevier |
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| Band: | 43 |
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| Nummer des Zeitschriftenheftes oder des Kapitels: | 49 |
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| Seitenbereich: | S. 8929-8933 |
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| Datum: | 2002 |
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| Zusätzliche Informationen (Öffentlich): | Times Cited: 10 |
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| Institutionen: | Chemie und Pharmazie > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger |
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| Identifikationsnummer: | | Wert | Typ |
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| ISI:000179238400030 | Web of Science | | 10.1016/S0040-4039(02)02195-0 | DOI |
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| Stichwörter / Keywords: | Escherichia-coli
precursor
thiamin
d-1-deoxyxylulose
5-phosphate
pyridoxol
thiazole |
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| Dewey-Dezimal-Klassifikation: | 500 Naturwissenschaften und Mathematik > 540 Chemie |
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| Status: | Veröffentlicht |
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| Begutachtet: | Ja, diese Version wurde begutachtet |
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| An der Universität Regensburg entstanden: | Nein |
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| Dokumenten-ID: | 11073 |
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Zusammenfassung
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-H-3]-6 and [1-H-2(1)]-6 from the same starting material in four steps where the hydrogen isotope is ...
Zusammenfassung
(E)-1-Hydroxy-2-methylbut-2-enyl 4-diphosphate (6) has been recently detected as an intermediate of isoprenoid biosynthesis via 1-deoxy-D-xylulose 5-phosphate. The compound was synthesized in two steps from 2-methyl-2-vinyloxirane with an overall yield of 72%. We also report a method affording [1-H-3]-6 and [1-H-2(1)]-6 from the same starting material in four steps where the hydrogen isotope is introduced in the last reaction step from deuterated or tritiated sodium borohydride. The radiochemical yield of [1-H-3]-6 was 15%. (C) 2002 Elsevier Science Ltd. All rights reserved.
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