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Studies on the nonmevalonate pathway to terpenes: The role of the GcpE (IspG) protein

Hecht, S., Eisenreich, W., Adam, P., Amslinger, S., Kis, K., Bacher, A., Arigoni, D. and Rohdich, F. (2001) Studies on the nonmevalonate pathway to terpenes: The role of the GcpE (IspG) protein. Proc. Natl. Acad. Sci. USA 98 (26), pp. 14837-14842.

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Recombinant Escherichia coli cells engineered for the expression of the xyIB gene in conjunction with genes of the nonmevalonate pathway were supplied with C-13-labeled 1-deoxy-D-xylulose. Cell extracts were analyzed directly by NMR spectroscopy. C-13-labeled 2C-methyl-D-erythritol 2,4-cyclodiphosphate was detected at high levels in cells expressing xyIB, ispC, ispD, ispE, and ispF. The ...


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Item type:Article
Additional Information (public):Times Cited: 79
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Dr. Sabine Amslinger
Identification Number:
ISI:000172848800021Web of Science ID
Keywords:isoprenoid biosynthesis 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate Escherichia-coli isoprenoid biosynthesis isopentenyl diphosphate 4-diphosphocytidyl-2c-methyl-d-erythritol 1-deoxy-d-xylulose atoms
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:No
Item ID:11074
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