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Studies on the nonmevalonate terpene biosynthetic pathway: Metabolic role of IspH (LytB) protein

Rohdich, F. ; Hecht, S. ; Gärtner, K. ; Adam, P. ; Krieger, C. ; Amslinger, S. ; Arigoni, D. ; Bacher, A. ; Eisenreich, W.



Abstract

Isopentenyl diphosphate and dimethylallyl diphosphate serve as the universal precursors for the biosynthesis of terpenes. Although their biosynthesis by means of mevalonate has been studied in detail, a second biosynthetic pathway for their formation by means of 1-deoxy-D-xylulose 5-phosphate has been discovered only recently in plants and certain eubacteria. Earlier in vivo experiments with ...

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