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Photoactivated coumaryl-diazopyruvate fluorescent label for amine functional groups of tissues containing type-I collagen

Timberlake, G. T. ; Reddy, G. K. ; Stehno-Bittel, L. ; Weber, J. F. ; Amslinger, S. ; Givens, R. S.


The design, synthesis and application of a new fluorescent-labeling reagent for collagen has been developed as a prerequisite for the design of a photoactivated collagen-crosslinking compound for surgical wound closure. The amine groups in collagen are the targets of a rational design for a new fluorophore because natural collagen crosslinks are formed between primary (1) amine groups of lysine ...


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