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Soluble Interleukin-2 Receptors Inhibit Interleukin 2-Dependent Proliferation and Cytotoxicity: Explanation for Diminished Natural Killer Cell Activity in Cutaneous T-Cell Lymphomas In Vivo?

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Dummer, Reinhard ; Posseckert, Gerhard ; Nestle, Frank ; Witzgall, Ralph ; Burger, Mathias ; Becker, Jürgen C. ; Schäfer, Erwin ; Wiede, Johannes ; Sebald, Walter ; Burg, Günter
Date of publication of this fulltext: 06 Dec 2010 09:14


In patients with cutaneous T-cell lymphomas (CTCL), soluble interleukin-2 receptor serum levels (sIL-2R) were determined by ELISA technique, and natural killer cell (NK) activity, by a 4-h chromium-51 release assay. Decrease of NK activity correlated with the augmentation of serum sIL-2R. After a 4-d stimulation with interleukin 2 CTCL patients' peripheral mononuclear cells (PMC) showed an ...


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