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The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression

URN to cite this document:
urn:nbn:de:bvb:355-epub-112078
Witzgall, Ralph ; O'Leary, Eilleen ; Leaf, Alexander ; Önaldi, Dilek ; Bonventre, Joseph V.
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Date of publication of this fulltext: 06 Dec 2010 09:16


Abstract (German)

We have previously reported the cloning, sequencing, and partial characterization of Kid-1, a zinc finger-encoding cDNA from the rat kidney. The Kid-1 protein and approximately one-third of all other zinc finger proteins contain a highly conserved region of approximately 75 amino acids at their NH2 terminus named Krüppel-associated box (KRAB), which is subdivided into A and B domains. The ...

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