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Polycefin, a new prototype of multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery

DOI to cite this document:
10.5283/epub.114
Lee, Bong-Seop ; Fujita, Manuba ; Khazenon, Natalya M. ; Wawrowsky, Kolja A. ; Wachsmann-Hogiu, Sebastian ; Farkas, Daniel L. ; Black, Keith L. ; Ljubimova, Julia Y. ; Holler, Eggehard
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Date of publication of this fulltext: 05 Aug 2009 13:21


Abstract

A new prototype of nanoconjugate, Polycefin, was synthesized for targeted delivery of antisense oligonucleotides and monoclonal antibodies to brain tumors. The macromolecular carrier contains: 1. biodegradable, nonimmunogenic, nontoxic -poly(L-malic acid) of microbial origin; 2. Morpholino antisense oligonucleotides targeting laminin 4 and 1 chains of laminin-8, which is specifically ...

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