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Polycefin, a new prototype of multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery

Lee, Bong-Seop, Fujita, Manuba, Khazenon, Natalya M., Wawrowsky, Kolja A., Wachsmann-Hogiu, Sebastian, Farkas, Daniel L., Black, Keith L., Ljubimova, Julia Y. and Holler, Eggehard (2006) Polycefin, a new prototype of multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery. Bioconjugate Chemistry 17 (2), pp. 317-326.

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Date of publication of this fulltext: 05 Aug 2009 13:21

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Other URL: http://dx.doi.org/10.1021/bc0502457, http://pubs.acs.org/cgi-bin/abstract.cgi/bcches/2006/17/i02/abs/bc0502457.html


Abstract

A new prototype of nanoconjugate, Polycefin, was synthesized for targeted delivery of antisense oligonucleotides and monoclonal antibodies to brain tumors. The macromolecular carrier contains: 1. biodegradable, nonimmunogenic, nontoxic -poly(L-malic acid) of microbial origin; 2. Morpholino antisense oligonucleotides targeting laminin 4 and 1 chains of laminin-8, which is specifically ...

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Item type:Article
Date:March 2006
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Identification Number:
ValueType
10.1021/bc0502457DOI
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:114
Owner only: item control page

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