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Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Ljubimova, J. Y. ; Fujita, M. ; Lee, B. S. ; Khazenzon, N. M. ; Wachsmann-Hogiu, S. ; Farkas, D. L. ; Black, K. L. ; Holler, E.


Abstract

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and protection. PMLA of microbial origin is non-toxic, nonimmunogenic, biodegradable and highly suited as a scaffold ...

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