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Guanidine-acylguanidine bioisosteric approach to address peptidergic receptors: pharmacological and diagnostic tools for the NPY Y1 receptor and versatile building blocks based on arginine substitutes

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Keller, Max
Date of publication of this fulltext: 16 Jan 2009 15:23

Abstract (English)

Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the central and peripheral nervous system. This 36-amino acid peptide is involved in the regulation of numerous physiological functions such as food intake, blood pressure, stress, nociception and hormone secretion. In humans, the action of NPY is mediated by four receptor subtypes (Y1, Y2, Y4 and Y5), members of the superfamily of ...


Translation of the abstract (German)

Neuropeptid Y (NPY) ist eines der am häufigsten vorkommenden Neuropeptide im zentralen und peripheren Nervensystem. Das 36-Aminosäuren-Peptid ist an der Regulation einer Vielzahl physiologischer Funktionen wie z.B. Nahrungsaufnahme, Blutdruck, Hormonfreisetzung und Nozizeption beteiligt. NPY-Effekte werden beim Menschen von vier Rezeptorsubtypen (Y1, Y2, Y4, Y5), die zur Familie der G-Protein ...


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