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Theoretical study of the interaction of agonists with the 5-HT2A receptor

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Silva, Maria Elena
Date of publication of this fulltext: 25 Feb 2009 15:24

Abstract (English)

The 5-HT2A receptor (5-HT2AR) is a biogenic amine receptor that belongs to the class A of G protein coupled receptors. It is characterized by a low affinity for serotonin (5-HT) and for other primary amines. Introduction of an ortho-methoxybenzyl substituent at the amine nitrogen increases the partial agonistic activity by a factor of 40 to 1400 compared with 5-HT. The present study was to ...


Translation of the abstract (German)

Der 5-HT2A-Rezeptor (5-HT2AR) ist ein Rezeptor für biogene Amine, gehört zur Klasse A der G-Protein gekoppelten Rezeptoren und hat niedrige Affinität für Serotonin (5-HT) und andere primäre Amine. Die Einführung eines ortho-Methoxybenzyl-Substituenten am Amino-Stickstoff steigert die partialagonistische Aktivität um das 40- bis 1400-fache gegenüber 5-HT. Die vorliegende Arbeit sollte die QSAR ...


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