Tissue microarray analysis of methylthioadenosine phosphorylase protein expression in melanocytic skin tumors

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.1219

Wild, Peter J. ; Meyer, Stefanie ; Bataille, Frauke ; Woenckhaus, Matthias ; Ameres, Markus ; Vogt, Thomas ; Landthaler, Michael ; Pauer, Armin ; Klinkhammer-Schalke, Monika ; Hofstaedter, Ferdinand ; Bosserhoff, Anja K.

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:26

Alternative Links zum Volltext:DOI Pubmed Verlag

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BACKGROUND: Using tissue microarrays, we investigated whether methylthioadenosine phosphorylase (MTAP) protein expression is associated with clinicopathologic variables in benign and malignant melanocytic skin tumors. OBSERVATIONS: Cytoplasmic MTAP expression was detected in 227 (72.1%) of 315 informative cases. Expression was significantly reduced in primary malignant melanomas and in melanoma ...