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Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells

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Memminger, Martin
Date of publication of this fulltext: 28 May 2009 13:44

Abstract (English)

The estrogen receptor (ER), a member of the nuclear receptor family, is the classical target of hormonal treatment of breast cancer. Recently, also individual membrane bound receptors have gained interest in both, diagnosis and possibe treatment of mammary carcinoma. Especially neuropeptide Y (NPY) receptors, belonging to the superfamily of G-protein coupled receptors, have become a topic in ...


Translation of the abstract (German)

Der Estrogen Rezeptor (ER), ein Mitglied der Superfamilie der nukleären Rezeptoren, ist das klassische Target für Hormone/Antihormone bei der Behandlung des Mammakarzinoms. Neuerdings rückten auch Vertreter der Superfamilie der G-Protein gekoppelten Rezeptoren, insbesondere Neuropeptid Y (NPY) Rezeptoren, in das Interesse der Brustkrebsforschung, nachdem die Expression des Y1 Rezeptor (Y1R) ...


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