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Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells

Memminger, Martin (2009) Synthesis and characterization of subtype-selective estrogen receptor ligands and their application as pharmacological tools - Cross-talk between estrogen and NPY Y1 receptors in human breast cancer cells. PhD, Universität Regensburg.

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Date of publication of this fulltext: 28 May 2009 13:44

Abstract (English)

The estrogen receptor (ER), a member of the nuclear receptor family, is the classical target of hormonal treatment of breast cancer. Recently, also individual membrane bound receptors have gained interest in both, diagnosis and possibe treatment of mammary carcinoma. Especially neuropeptide Y (NPY) receptors, belonging to the superfamily of G-protein coupled receptors, have become a topic in ...

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Translation of the abstract (German)

Der Estrogen Rezeptor (ER), ein Mitglied der Superfamilie der nukleären Rezeptoren, ist das klassische Target für Hormone/Antihormone bei der Behandlung des Mammakarzinoms. Neuerdings rückten auch Vertreter der Superfamilie der G-Protein gekoppelten Rezeptoren, insbesondere Neuropeptid Y (NPY) Rezeptoren, in das Interesse der Brustkrebsforschung, nachdem die Expression des Y1 Rezeptor (Y1R) ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:27 May 2009
Referee:apl. Prof. Dr Günther Bernhardt
Date of exam:24 March 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Keywords:Neuropeptid Y , Brustkrebs , Östrogene , Antiöstrogene , Östrogenrezeptor , Struktur-Aktivitäts-Beziehung , Krebszelle , Estrogen Rezeptor , Neuropeptid Y Y1 Rezeptor , Brustkrebszellen , Estrogen Rezeptor Subtyp , estrogen receptor , neuropeptide Y Y1 receptor , breast cancer cells , estrogen receptor subtype
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12274
Owner only: item control page

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