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Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins

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Göttle, Martin
Date of publication of this fulltext: 24 Jul 2009 14:08

Abstract (English)

The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure. As mammalian AC isoforms are expressed in a tissue-specific manner, isoform-selective AC activation or inhibition may be a promising novel therapeutic strategy. Therefore, the aim of this doctoral thesis was to ...


Translation of the abstract (German)

Die Bildung des �Second Messengers� cAMP durch Adenylylcyclasen (AC) ist von essentieller Bedeutung in Zusammenhang mit vielen physiologischen Prozessen und Krankheitszuständen wie zum Beispiel neurodegenerativen Erkrankungen, Depression, Schmerz, Drogenabhängigkeit und Herzinsuffizienz. Da die AC-Isoformen gewebsspezisch exprimiert werden, stellt Isoform-selektive Stimulation oder Hemmung der AC ...


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