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Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins

Göttle, Martin (2009) Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins. PhD, Universität Regensburg.

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Date of publication of this fulltext: 24 Jul 2009 14:08

Abstract (English)

The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure. As mammalian AC isoforms are expressed in a tissue-specific manner, isoform-selective AC activation or inhibition may be a promising novel therapeutic strategy. Therefore, the aim of this doctoral thesis was to ...


Translation of the abstract (German)

Die Bildung des �Second Messengers� cAMP durch Adenylylcyclasen (AC) ist von essentieller Bedeutung in Zusammenhang mit vielen physiologischen Prozessen und Krankheitszuständen wie zum Beispiel neurodegenerativen Erkrankungen, Depression, Schmerz, Drogenabhängigkeit und Herzinsuffizienz. Da die AC-Isoformen gewebsspezisch exprimiert werden, stellt Isoform-selektive Stimulation oder Hemmung der AC ...


Export bibliographical data

Item type:Thesis of the University of Regensburg (PhD)
Date:23 July 2009
Referee:Roland (Prof. Dr.) Seifert
Date of exam:17 July 2009
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Keywords:Cyclonucleotide , Sekundärer Bote , Säugetiere , Adenylatcyclase , Bakterien , Toxin , Adenylylcyclase , Bakterielle Adenylylcyclase-Toxine , adenylyl cyclase , bacterial adenylyl cyclase toxins
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:12313
Owner only: item control page


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