Acrylate and methacrylate esters: relationship of hemolytic activity and in vivo toxicity.

URN to cite this document:: urn:nbn:de:bvb:355-epub-124533
DOI to cite this document:: 10.5283/epub.12453

Dillingham, E. O. ; Lawrence, W. H. ; Autian, J. ; Schmalz, Gottfried

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Date of publication of this fulltext: 17 Feb 2010 15:22

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Abstract

Quantitative hemolysis assays of acrylate and methacrylate esters provided estimates of the intrinsic hemolytic activity (Hi, the slope of the concentration-response curve) and the concentrations effecting 5% (H5) and 50% (H50) hemolysis. The dependence of hemolytic activity and LD50 (mice) on physical properties (lipophilicity, molar refraction, and molecular volume) of the esters was determined ...