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Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA

URN to cite this document:
Götze, Hannah
Date of publication of this fulltext: 20 Apr 2010 11:25

Abstract (English)

Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a genomic locus. An excellent example to study the correlation between transcription and chromatin structure is the ribosomal DNA (rDNA) locus in ...


Translation of the abstract (German)

Der Upstream Activating Factor UAF spielt eine wichtige Rolle bei der Regulation der Transkription der ribosomalen RNA Gene durch Polymerase I in S. cerevisiae. UAF ist ein Multiproteinkomplex bestehend aus den 6 Untereinheiten Rrn5, Rrn9, Rrn10, Uaf30, und den Histonen H3 und H4. Die Bindung von UAF an den rDNA Promotor stimuliert die Transkription der rRNA Gene. Gleichzeitig determiniert UAF ...


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