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Function of the upstream activating factor in chromatin structure organization and transcriptional regulation at the yeast ribosomal DNA

URN to cite this document:
urn:nbn:de:bvb:355-epub-125586
Götze, Hannah
Date of publication of this fulltext: 20 Apr 2010 11:25


Abstract (English)

Chromatin is the template of all processes involved in DNA metabolism in the eukaryotic cell. Accordingly, chromatin is a dynamic structure which changes in its composition and posttranslational modification correlating with the functional state of a genomic locus. An excellent example to study the correlation between transcription and chromatin structure is the ribosomal DNA (rDNA) locus in ...

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Translation of the abstract (German)

Der Upstream Activating Factor UAF spielt eine wichtige Rolle bei der Regulation der Transkription der ribosomalen RNA Gene durch Polymerase I in S. cerevisiae. UAF ist ein Multiproteinkomplex bestehend aus den 6 Untereinheiten Rrn5, Rrn9, Rrn10, Uaf30, und den Histonen H3 und H4. Die Bindung von UAF an den rDNA Promotor stimuliert die Transkription der rRNA Gene. Gleichzeitig determiniert UAF ...

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